降低病原体的技术,在不止一个方面对细胞血液成分有好处,正在取代辐射
1Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA; Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.
概括
病原体减少技术 (PRT) 通过非活化白细胞提供了增强的输血安全性. 将PRT扩展到包括红细胞在内的所有细胞血组成部分,可以显著提高全球患者的安全性.
科学领域:
- 输血医学 输血医学
- 血液安全技术 血液安全技术
- 微生物学 微生物学
背景情况:
- 目前的病原体减少技术 (PRT) 主要用于血小板和非细胞血液成分.
- 红细胞 (RBC) 不常用PRT治疗,限制了其对患者安全的全部潜力.
- 白细胞失活对于输血安全至关重要,PRT比目前的辐射方法更有效.
研究的目的:
- 评估病原体减少技术 (PRT) 在输血医学中更广泛应用的潜力.
- 突出PRT在所有细胞血液成分中的白细胞失活方面的好处.
- 讨论输血医学的战略机会,以普遍实施PRT.
主要方法:
- 审查PRT目前的临床应用.
- 将PRT的疗效与现有的白细胞减少方法 (辐射) 的比较.
- 对PRT处理组件的监管豁免的分析.
主要成果:
- 与目前的辐射技术相比,PRT在禁用白细胞方面更有效.
- 经批准的PRT系统允许豁免对特定患者需要的辐射要求.
- 全球PRT应用可以实现血液供应中100%的白细胞失活.
结论:
- 将PRT扩展到所有细胞血液成分,不包括造血原生细胞,代表了输血安全的重大进步.
- PRT提供了一种战略途径,通过确保通用白细胞失活来提高患者的安全性.
- 采用PRT用于全基血组件,对输血医学具有最大的潜在益处.
关键词:
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