咖啡因摄入量与不同葡萄糖状况的肝纤维化风险降低有关
Jiahao Han1, Chuan Liu2, Huanhuan Yang3
1Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Nanjing, China; Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University, State Key Laboratory of Digital Medical Engineering, Nanjing, China; Department of Ultrasound, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
较高的每日咖啡因摄入量 (≥78毫克) 与成人肝纤维化风险降低有关,特别是在2型糖尿病或糖尿病前期患者中. 这表明咖啡因可能有保护作用,防止肝病的进展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养流行病学 营养流行病学
背景情况:
- 肝纤维化风险在葡萄糖代谢受损的个体中较高.
- 了解咖啡因等饮食因素对肝脏健康的影响至关重要.
研究的目的:
- 为了确定不同葡萄糖代谢状态的肝纤维化患病率.
- 调查咖啡因消费与肝纤维化风险之间的关联.
主要方法:
- 从国家健康和营养检查调查 (2005-2020) 中对23,711名成年人的横截面分析.
- 分类为2型糖尿病 (T2DM),糖尿病前期和无糖尿病组.
- 使用纤维化-4指数和通过24小时饮食回忆摄入咖啡因来评估肝纤维化风险.
主要成果:
- 与糖尿病前期 (3.2%) 和无糖尿病 (2.5%) 组相比,2型糖尿病患者的肝纤维化风险显著增加 (5.9%).
- 每天摄入≥78毫克咖啡因与所有葡萄糖代谢亚组中肝纤维化风险显著降低有关.
- 较低纤维化风险与较高咖啡因摄入量的几率比率在各组之间从0.553到0.720 (P <0.05) 之间.
结论:
- 肝纤维化在2型糖尿病和糖尿病前期患者中很普遍.
- 对于糖尿病前期患者,建议对肝纤维化进行查.
- 每天摄入≥78毫克的咖啡因显示出对肝纤维化的保护性关联.
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