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生物模拟补充皮质醇疗法使用半固体挤出 - - 针对上腺功能缺陷的3D打印片
Pankti Ganatra1, Alice Ashapogu2, Rashmita Epili1
1Department of Biological Sciences and Biotechnology, Institute of Chemical Technology, Mumbai 400019, India.
International journal of pharmaceutics
|February 13, 2025
概括
个性化的3D打印平板电脑为上腺功能衰竭治疗提供了一种新的解决方案. 这种核心外平板电脑设计可以控制夜间皮释放,改善患者的坚持和治疗结果.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 3D打印应用 3D打印应用
背景情况:
- 上腺功能不全需要每天进行皮替代疗法.
- 皮的药理动力学在患者之间有很大差异,需要个性化剂量.
- 传统的剂量形式难以复制皮质醇的自然昼夜节律,特别是夜间释放.
研究的目的:
- 开发一个个性化的,使用半固体挤出3D打印的皮的慢性治疗剂型.
- 为了创建一个能够促进夜间皮释放的核心片.
- 解决现有配方在满足患者特定需求和实现准确的时间释放方面的局限性.
主要方法:
- 使用平板电脑中的平板电脑 (核心外) 方法与半固体挤出3D打印.
- 使用KlucelTM HF作为延迟释放的速度限制障碍物制定了一个外.
- 开发了一种含有皮,稀释剂和KlucelTM JF凝的核心,优化了病学和可打印性.
- 确定了最佳的打印参数 (喷嘴尺寸,速度,层高度),并进行了全面的物理化学表征.
主要成果:
- 成功制造出具有可控药物释放概况的核心外片.
- 确定了核心和外配方的最佳打印参数.
- 具有破裂力,易碎性,药物含量和结构完整性 (FTIR,X射线衍射,SEM) 的特征的片.
- 已证明有效的体外药物释放,表明长期治疗的潜力.
结论:
- 半固体挤出3D打印是一种可行的技术,用于创建个性化,慢疗药片.
- 开发的核心外平板电脑设计成功地使夜间皮释放.
- 这种方法具有显著的潜力,可以改善患者对上腺功能不全的治疗遵从性和坚持性.
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