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在克罗恩病患者的纤维化肠道组织和介质脂肪组织中积聚微塑料

Fengfei Wu¹, Fangting Wu¹, Xi Liu¹

¹Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Environmental research

|February 13, 2025

概括

微塑料 (MP) 在克罗恩病 (CD) 患者的纤维化肠道中积累,其较高度与肠道纤维化增加有关. 侵入性手术可能会恶化肠道中MP的积累.

科学领域:

胃肠病学胃肠病学
环境健康环境健康
材料科学材料科学材料科学

背景情况:

克罗恩病 (CD) 患者容易受到环境因素的影响.
微塑料 (MPs) 在CD病变发生过程中的作用尚不清楚.
国会议员是无处不在的环境污染物,具有潜在的健康影响.

研究的目的:

调查克罗恩病 (CD) 患者的肠组织和介质脂肪组织中微塑料 (MPs) 的存在和特征.
为了确定MP污染和CD中肠道纤维化严重程度之间的相关性.
探索MP在CD肠道中积累的潜在来源和机制.

主要方法:

从CD患者对配合的参与和不参与的叶片段和相邻的介质脂肪组织的分析.
使用激光红外成像光谱学和激光直接红外光谱学识别和量化MPs.
在MP度,MP大小分布和肠道纤维化程度之间的相关性分析.

主要成果:

在CD患者的组织中检测到12种MP类型 (例如,化聚乙烯,烯酸共聚合物) 的广泛污染.
MP度与肠道纤维化的严重程度正相关.
频繁的侵入性胃肠道检查被确定为加剧纤维化肠道中MP积累的潜在因素.

结论:

这项研究提供了第一个证据,表明克罗恩病患者的纤维化肠道和相关脂肪组织中存在显著的微塑料污染.
微塑料可能会穿透上皮质屏障,并导致肠道纤维化和CD中的爬行脂肪的恶化.
需要进一步的研究来阐明MPs影响CD进展的确切机制.

关键词:

爬行爬行的脂肪脂肪的人.克罗恩氏病克罗恩氏病是什么?肠道纤维化肠道纤维化微塑料是一种微塑料.

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