唐氏综合征是鼻管支架后发展角膜的危险因素
Brittany Marks1, Michael A Puente2
1University of Colorado School of Medicine, Aurora, Colorado.
概括
鼻管支架治疗先天性阻塞,但可能导致角膜. 患有唐氏综合征的儿童在支架安置后患上这些的风险明显更高.
科学领域:
- 眼科医生 眼科 眼科
- 儿科手术 儿科手术
背景情况:
- 在婴儿中,先天性鼻管阻塞 (NLDO) 是常见的.
- 鼻管支架是NLDO的标准治疗方法.
- 角膜是一种罕见但严重的支架安置并发症.
研究的目的:
- 研究在患有先天性NLDO的儿童中,在单管支架植入后出现角膜的发生率和危险因素.
- 为了确定患有唐氏综合征的儿童在支架安置后是否有角膜的风险增加.
主要方法:
- 在33个月的时间里,对253名先天性NLDO患者进行了回顾性图表审查,这些患者接受了349个单通道支架的治疗.
- 分析并发症的发生率,特别是角膜.
- 唐氏综合征儿童与其他患者之间发病率的统计比较.
主要成果:
- 四个支架 (1.1%) 导致角膜.
- 在35名患有唐氏综合征的儿童中,发生了3起 (9%).
- 在剩余的患者中发生了一种 (0.46%),这是统计学上显著的差异 (相对风险 = 18.68;P = 0.0102).
结论:
- 角膜的形成是对先天性NLDO的单通道支架的罕见并发症.
- 患有唐氏综合征的儿童在支架后出现角膜的风险显著增加.
- 眼科医生应对患有唐氏综合征的儿科患者进行鼻管支架的角膜并发症保持高度警.
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