扩张性功能障碍:肝移植候选人的患病率和结果
Francis Voet1, Maxim Khalenkow1, Michel De Pauw2
1Department of Gastroenterology and Hepatology, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Hepatology Research Unit, Department Internal Medicine and Pediatrics, Liver Research Center, Corneel Heymanslaan 10, 9000, Ghent University, Belgium.
Annals of hepatology
|February 13, 2025
概括
修订后的标准在6.4%的肝移植候选人中发现了腹功能障碍 (DD). 扩张功能障碍没有显著影响LT后的存活率或主要的不良心血管事件.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
背景情况:
- 循环性心肌病变 (CCM) 是肝硬化的一种心脏并发症,主要表现为扩张性功能障碍 (DD).
- 2019年更新了DD的诊断标准,需要重新评估其在肝移植 (LT) 候选人的流行率和影响.
研究的目的:
- 通过使用原始 (2005年) 和修订 (2019年) 标准,确定肝移植 (LT) 候选人中扩张性功能障碍 (DD) 的患病率.
- 评估DD对等待名单死亡率,LT率和LT后结果的临床影响,包括生存率和主要心血管不良事件.
主要方法:
- 对233名成年肝硬化LT候选人的心声学数据进行了回顾性分析.
- 使用2005年和2019年标准对DD进行分类.
- 临床特征的比较,等候名单死亡率,LT率和DD和无DD的患者之间的LT后结果.
主要成果:
- 使用原始标准,DD的患病率为72.1%,使用修订标准,DD的患病率为6.4%.
- 根据修订的标准,患有DD的患者年龄较大;其他特征相似.
- 等候名单死亡率,LT率和LT后生存率在各组之间是可比的,尽管LT前较低的e'横向值与LT后死亡率相关.
- 移植后的主要不良心血管事件在两组之间没有显著差异.
结论:
- 修订后的标准发现,在LT候选人中,DD的发病率较低 (6.4%).
- 根据修订后的标准定义,透支功能障碍并没有显著影响整体移植后死亡率或重大心血管不良事件.
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