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对克拉米迪亚和淋病的合作伙伴治疗策略:是时候重新评估了
Lea Ben Said1, Anne Conrad2, Sander De Souza1
1Faculté de Médecine Lyon-Est, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, 69003 Lyon, France.
对克拉米迪亚虫 (CT) 和尼塞利亚淋病 (NG) 的流行病学治疗导致无症状伴侣中60%的抗生素过度使用. 在治疗前等待实验室结果可以显著减少不必要的抗生素使用.
科学领域:
- 性健康 性的健康
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 对疑似冠状病毒 (CT) 和尼塞利亚淋病 (NG) 的流行病学治疗是暴露性伴侣的标准做法.
- 这种方法旨在减少症状,传播和对随访的损失.
- 然而,它可能会导致未感染个体不必要使用抗生素,从而导致抗菌素耐药性.
研究的目的:
- 调查CT和NG感染的流行病学治疗的准确性.
- 评估无症状暴露性伴侣之间潜在过度使用抗生素的比率.
- 评估与过度使用抗生素相关的因素.
主要方法:
- 对无症状暴露的伴侣进行了回顾性横截面分析,这些伴侣被假定为CT/NG.治疗.
- 评估阳性测试率和不必要的抗生素治疗的频率.
- 评估过度使用抗生素与艾滋病毒暴露前预防,年龄,性别,性取向和接触类型之间的关联.
主要成果:
- 测试与报告暴露之间的一致性为CT的44.8%,NG的28.1%.
- 潜在的过度使用抗生素发生在59.6%的患者中.
- 对CT而言,过度使用抗生素的频率低于NG,对女性和异性恋个体来说更低.
结论:
- 在开始CT/NG治疗之前等待实验室诊断是一个合理的策略.
- 这种方法可以防止近60%的不必要的抗生素治疗无症状暴露的合作伙伴.
- 优化治疗方案可以减轻对抗菌素耐药性的担忧.
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