肠道微生物群的动态变化在脑衰老期间通过SCFA和LPS合成代谢途径在与年龄相关的认知功能障碍中发挥着关键作用
Xiaoying Ma1, Jiaying Liu2, Lei Jiang2
1Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang 050031, PR China; Hebei International Joint Research Center for Brain Science, Shijiazhuang 050031, PR China; Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang 050031, PR China; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Hebei Province, Shijiazhuang 050017, PR China.
International journal of biological macromolecules
|February 13, 2025
概括
肠道细菌的变化与衰老中的认知能力下降有关. 这项研究确定了关键的细菌群体和代谢途径,如短链脂肪酸 (SCFA),涉及与年龄相关的认知功能障碍.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 肠道微生物群在衰老过程中显著影响认知功能下降.
- 与肠道细菌组成的年龄相关的变化与认知障碍有关.
研究的目的:
- 为了研究在自然衰老过程中动态肠道微生物群的变化.
- 为了确定关键的肠道细菌种群与与年龄相关的认知功能障碍相关.
- 探索肠道微生物群在老化小鼠和人类认知衰退中的作用.
主要方法:
- 来自老化小鼠和人类队伍的便样本的16S rRNA基因测序 (认知正常和缓和认知障碍).
- 在老化小鼠模型中的便微生物群移植 (FMT).
- 利用GMrepo数据库进行跨物种分析.
主要成果:
- 肠道微生物群的组成随着老龄化在老鼠和人类动态变化.
- 在老年小鼠中,FMT改善了认知障碍,改变了肠道微生物群.
- 关键的种类 (Lactobacillus,Akkermansia,Clostridium,Oscillospira,Dorea) 与认知能力下降相关.
- 涉及短链脂肪酸 (SCFA) 和脂多糖 (LPS) 合成的新陈代谢途径.
结论:
- 在大脑衰老过程中,肠道微生物群的组成会有动态变化.
- 特定的肠道细菌种类在与年龄相关的认知功能障碍中发挥着关键作用.
- SCFA和LPS合成途径是将肠道微生物群与认知衰老联系起来的关键机制.
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