含有氨酸嵌入的多孔粉的碳素甲基纤维素水凝珠:一种肠道药物输送系统
Xueze Zhang1, Shuqi Guo1, Wuyang Niu2
1College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China; Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Ministry of Education, Taiyuan 030024, PR China.
International journal of biological macromolecules
|February 13, 2025
概括
使用多孔粉 (PS) 和碳甲基纤维素 (CMC) 开发了一种新的肠道药物输送系统. 这种系统有效地封装Quercetin (Que),并在pH值为7.4的环境中释放它,显示有希望的目标肠道输送.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 材料化学 材料化学
背景情况:
- 开发有效的肠道药物输送系统对于改善治疗结果至关重要.
- 基于粉的材料为药物封装提供生物相容性和生物降解性.
- 碳氧甲基纤维素 (CMC) 可以形成适合控制释放应用的水凝.
研究的目的:
- 设计和表征一种使用多孔粉 (PS) 和碳甲基纤维素 (CMC) 的新型肠道药物输送系统.
- 在开发的系统中评估一个模型药物 (quercetin) 的吸附,加载和封装效率.
- 评估药物从肠道输送的水凝珠中释放的pH敏感特征.
主要方法:
- 多孔粉 (PS) 是从原生粉 (NS) 通过使用α-氨基酶 (AM) 和氨基葡萄糖酶 (AMG) 的酶性水解合成的.
- 模型药物素 (Que) 被吸附到PS上,并使用SEM和BET表面积分析来表征产生的QPS.
- 用素加载的多孔粉 (QPS) 被封装在CMC水凝珠 (QPS/CMC) 中,并在pH7.4.4下对药物负载,封装效率,胀和体外释放进行了评估.
主要成果:
- SEM证实了多孔粉 (PS) 的成功形成.
- 素 (Que) 在PS上的吸附效率达到了86.48%.
- QPS/CMC水凝珠的药物负载能力为8.57±0.15%,封装效率为89.73±1.20%.
- 水凝珠显示了pH敏感的胀和药物释放,在pH值7.4.4时观察到显著的释放.
结论:
- 开发的多孔粉和碳甲基纤维素系统有效地吸附和封装奎尔丁.
- QPS/CMC水凝珠显示出有希望的pH敏感释放特性,适合肠道药物输送.
- 这种新的系统有可能有针对性地将药物输送到肠道.
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