水脑病对[18F] - - 氧葡萄糖正子发射断层扫描的影响 统计参数映射分析在神经退行性疾病评估中的分析
Andres Ricaurte-Fajardo1, Ana M Franceschi1, Debra D' Angelo1
1From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA.
脑水性脑部显著影响大脑[18F]氧葡萄糖正子发射断层扫描 (FDG-PET) 分析,特别是在对痴呆症评估至关重要的环状回膜区域. 这种陷可以降低认知障碍患者的诊断准确度.
科学领域:
- 神经成像是一种神经成像.
- 核医学就是核医学.
- 神经学 神经学
背景情况:
- 大脑[18F]氧葡萄糖正子发射断层扫描 (FDG-PET) 对于诊断神经退行性疾病至关重要.
- 使用统计参数映射 (SPM) 的定量分析提高了FDG-PET的诊断准确性,并用于临床.
- 环状回形区域是痴呆症评估的关键,并与侧腔室相邻.
研究的目的:
- 评估水脑对FDG-PET SPM分析准确性的影响.
- 专门研究对带带带部区域 (前,中,后) 的影响,这对痴呆症评估至关重要.
主要方法:
- 对48名患有认知障碍和沟通性水头的患者进行了回顾性研究,这些患者接受了FDG-PET/CT或PET/MRI.
- 在SPM分析中,针对 cingulate gyri和小脑产生了特定区域的Z-score.
- 量化SPM结果与使用卡帕系数和配对t测试的盲目专家定性评估进行比较.
主要成果:
- 在SPM分析中,与小脑相比, cingulate gyri (前,中,后) 的Z-score显著较低 (p < 0.0001).
- 配对的t测试证实,在所有带皮带区域与小脑相比,Z分数显著较低 (p < 0.001).
- 在定量SPM和定性评估之间观察到不良一致性 (kappa 0.05-0.19).
结论:
- 在FDG-PET SPM分析中,水脑代表了一个重要的陷,特别是在带状带区域.
- 对这种陷的认识对于提高痴呆症评估的诊断准确性至关重要.
- 解决这个问题可以导致水头和认知障碍患者的更好的临床结果.

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