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2023年OPTN/SRTR 年度数据报告:肝脏

Allison J Kwong1, W Ray Kim2, John R Lake3

  • 1Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA.

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概括

在2023年,在美国进行了创纪录的10,659次肝移植,这是由于扩大了捐赠者标准和新的评分系统所推动的. 尽管有进展,但移植率和移植前死亡率的性别差异仍然存在.

关键词:
肝脏移植 肝脏移植肝脏捐赠 肝脏捐赠结果就是结果.在等待名单上.

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 移植手术 移植手术
  • 公共卫生 公共卫生

背景情况:

  • 肝移植是末期肝病的关键治疗方法.
  • 供体器官的可用性和分配系统对移植结果产生重大影响.
  • 解决获得护理的差异是移植的一个关键挑战.

研究的目的:

  • 报告美国2023年全国肝移植统计数据.
  • 分析捐赠者利用的趋势,包括循环死亡后捐赠 (DCD) 和活体捐赠.
  • 评估更新的末期肝病模型 (MELD) 3.0和儿科末期肝病 (PELD) 评分系统对移植公平性的影响.

主要方法:

  • 分析2023年起的国家肝移植数据.
  • 对捐赠者的特征进行审查,包括年龄和DCD状态.
  • 根据性别对移植率和移植前死亡率的评估以及更新的MELD/PELD得分.

主要成果:

  • 进行了创纪录的10,659次肝移植,增长归因于老年人和DCD捐赠者.
  • 恢复肝脏的不使用率降至9.7%,其中16.7%的接受者接受了DCD肝脏.
  • MELD 3.0/PELD更新缩小了已故供体肝移植率的性别差异,但男性仍然以更高的比例接受移植.

结论:

  • 肝移植的增加凸显了器官恢复和利用方面的进步.
  • 更新的MELD/PELD评分系统有望减少肝移植分配中的基于性别的差异.
  • 需要继续努力,以解决女性候选人移植前死亡率和移植率的剩余不平等问题.