在局部晚期和转移性激素敏感前列腺癌的组合疗法
Arun A Azad1, Louise Kostos1, Neeraj Agarwal2
1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne Australia.
European urology
|February 13, 2025
概括
组合疗法可以改善晚期前列腺癌的存活率,特别是在特定的患者群体. 早期治疗强化可以带来更好的结果,但也可能导致长期毒性.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 晚期前列腺癌的治疗已经发展到新的疗法,如多塞和雄激素受体通路抑制剂 (ARPI).
- 目前的策略强调使用组合疗法进行早期治疗强化,用于局部晚期和转移性激素敏感前列腺癌 (mHSPC).
研究的目的:
- 审查当前关于局部高级和mHSPC组合疗法的证据.
- 总结前列腺癌治疗强化治疗的好处和风险.
主要方法:
- 一个文献搜索进行到2024年11月.
- 关键词包括"转移性激素敏感前列腺癌"",组合疗法"和"治疗强化".
- 文章的选择是基于科学价值和临床相关性.
主要成果:
- 抗雄激素剥夺疗法 (ADT) 加上ARPI是mHSPC的标准;对于特定的子组,考虑使用多塞的三重疗法.
- 在局部和局部晚期疾病中,结合疗法正在与标准治疗一起进行评估.
- 改善生存率已经将重点转移到优化患者选择强化和降级以最大限度地降低毒性.
结论:
- 早期加剧治疗并加上组合疗法,可改善前列腺癌特定亚组的生存率.
- 长期毒性是与这些强化治疗方法相关的潜在问题.
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