与自免疫性疾病的发展相关的参数在儿科发病的乳病中
Firas Abu Hanna1,2, Maia Sirkin3, Bar Sofer Ilovich4
1Pediatric Gastroenterology Unit, Emek Medical Centre, Afula, Israel. ferass@gmail.com.
European journal of pediatrics
|February 13, 2025
概括
儿童腹膜炎患者能够及时实现组织转质胺酶 (TTG) 水平的正常化,并将其保持在一定值以下,其患其他自身免疫性疾病的风险较低.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 自身免疫性疾病研究研究
背景情况:
- 儿童腹腔疾病 (CeD) 患者面临患其他自身免疫性疾病 (ADs) 的风险较高.
- 儿童CeD中AD发展的预测因素仍然不完全理解.
研究的目的:
- 在被诊断为CeD的儿童中确定ADs发展的预测因子.
- 评估组织转谷氨酶 (TTG) 水平对随后的AD发展的影响.
主要方法:
- 对790名儿科CeD患者的回顾性分析,随访时间中位数为4.9年.
- 数据收集包括人口统计,临床数据和实验室变量,重点关注TTG水平.
- 用多变量考克斯模型来确定AD发展的风险因素.
主要成果:
- 16%的患者患上了1型糖尿病,4.4%患上了哈西莫托甲状腺炎,1.3%患上了其他AD.
- 较短的TTG正常化时间 (HR 0.94) 和持续的TTG水平 <3x ULN (HR 0.87) 与AD风险降低有关.
- 持续血清性缓解的患者与没有持续血清性缓解的患者相比,AD的发病率较低 (7.6%).
结论:
- 对 CeD 的有效管理,专注于及时的 TTG 规范化,至关重要.
- 持续较低的TTG水平似乎是减轻儿科CeD患者后续ADs风险的一个重要因素.
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