相关实验视频

Updated: May 28, 2025

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
08:53

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

394

银离子 (Ag+) 和粉样β (Aβ) 之间的分子相互作用,结构效应和结合亲和力

Amanda L Lakela1, Elina Berntsson1,2,3, Faraz Vosough1

  • 1Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, 10691, Stockholm, Sweden.

Scientific reports
|February 13, 2025
PubMed
概括

单价银离子 (Ag+) 与粉样β (Aβ) 结合,可能影响阿尔茨海默病的病理学. 然而,银离子对Aβ42寡合体结构的影响很小,这表明对毒性的影响有限.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.粉样蛋白聚合物的聚合.金属有毒性金属有毒性金属与蛋白质的结合.神经退行发生神经退行.频谱学是一种光谱学.

更多相关视频

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

11.8K
Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices04:41

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Published on: July 14, 2010

23.1K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.2K
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
23.2K
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
12.8K