对分子耐药性和结核病相关风险因素的分析
Zhenzhen Wang1,2, Tengfei Guo1, Liyang Xu3,2
1The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luo Yang, 471003, China.
BMC infectious diseases
|February 13, 2025
概括
高率的第一线抗结核药物耐药性持续存在,影响诺基诺的有效性. 这项研究强调迫切需要加强耐药结核病监测和针对性干预措施,以打击结核病的传播.
科学领域:
- 微生物学 微生物学
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 对抗结核病第一线药物和诺基诺 (FQs) 的分子耐药性的局部监测数据有限,这阻碍了有效的结核病控制.
- 耐药结核病 (DR-TB) 构成了全球重大卫生挑战,需要持续监测耐药性模式.
研究的目的:
- 在洛阳市对一线抗结核药物和FQs的分子耐药性进行调查.
- 为了确定与FQs耐药性相关的风险因素.
- 为改善控制策略提供对抗药性结核病传播的见解.
主要方法:
- 从2019年1月到2023年12月使用光实时PCR分析了25,150个唾液样本.
- 通过多色化曲线分析 (MMCA) 对4131种Mycobacterium结核综合体 (MTBC) 菌株对一线抗结核药物和FQs的分子耐药性评估.
- 对FQs耐药性和第一线药物耐药性的影响的风险因素的统计评估.
主要成果:
- 第一线抗结核病药物耐药性在男性,退治患者,年轻人和城市居民中更为普遍.
- 整体FQ的抗性率为7.9% (327例).
- 一线药物耐药性,包括异化,利法和乙醇耐药性,显著增加了FQs耐药性的几率.
结论:
- 高一线抗结核药物耐药性需要在治疗方案中仔细考虑FQs.
- 增加的FQs耐药性会影响DR-TB治疗的有效性.
- 加强DR-TB监测和及时干预对于实现终结结核病战略目标至关重要.
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