在泛癌患者中发现与左心室心脏功能障碍相关的血蛋白和代谢物
Jessica C Lal1,2,3,4, Michelle Z Fang5,6, Muzna Hussain7
1Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. jclal@mdanderson.org.
Cardio-oncology (London, England)
|February 13, 2025
概括
这项研究确定了与癌症患者左心室功能障碍 (LVD) 相关的特定血蛋白和代谢物. 这些生物标志物可能有助于非侵入性地检测LVD并揭示疾病途径.
科学领域:
- 心脏瘤学是一门专业.
- 蛋白质组学是指蛋白质组学.
- 代谢学 代谢学 代谢学
- 机器学习 机器学习
背景情况:
- 癌症治疗相关心脏功能障碍 (CTRCD) 是癌症幸存者死亡的主要原因.
- 左心室功能障碍 (LVD) 是CTRCD的一个关键组成部分.
- 在癌症患者中确定LVD的生物标志物对于早期检测和管理至关重要.
研究的目的:
- 在癌症患者中识别与LVD相关的差异性血蛋白和代谢物.
- 探索潜在的非侵入性生物标志物用于LVD检测.
- 为了深入了解癌症幸存者的LVD背后的分子机制.
主要方法:
- 分析了50名癌症患者的数据,这些患者接受了心声回声扫描.
- 电子健康记录,蛋白质组和代谢组资料的整合.
- 基于分类的机器学习模型的应用,以使用等离子体生物标志物预测LVD.
主要成果:
- 鉴定了13种与LVD显著相关的血蛋白和14种与LVD显著相关的血代谢物 (P < 0.05).
- 关键蛋白质包括炎症标志物 (例如ST2,TNFRSF14) 和化学反应 (例如RARRES2,MMP-2).
- 观察到的性别特异性关联 (例如,男性的尿素) 和代谢特征 (例如,1-甲基-4-伊米达酸),表明代谢转变和炎症.
结论:
- 循环中的代谢物和蛋白质可以在患有LVD的癌症患者中非侵入性检测临床和分子差异.
- 这些发现为疾病途径和CTRCD的潜在治疗点提供了宝贵的见解.
- 进一步的研究可以利用这些生物标志物用于早期LVD检测和个性化治疗策略.
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