过度的维生素B度比缺乏在神经性厌食症患者中更常见:一个横截面研究
Yusuke Saito1, Toshinori Shirata2, Keisuke Noto1
1Department of Psychiatry, Yamagata University Faculty of Medicine, Iidanishi, Yamagata, Japan.
Journal of eating disorders
|February 13, 2025
概括
高维生素B12水平,而不是缺乏,在神经性厌食症 (AN) 中很常见. 在AN患者的常规B12补充剂可能需要重新考虑,因为它可能与饥饿诱导的自有关.
科学领域:
- 营养科学 营养科学
- 临床生物化学 临床生物化学
- 厌食症神经性研究研究 厌食症神经性研究
背景情况:
- 维生素B12对单碳代谢至关重要,其缺乏可以导致身体和神经系统问题.
- 准则通常建议多维生素补充剂用于神经性厌食症 (AN) 患者,以防止缺乏.
- 在AN患者中观察到维生素B12水平升高,这促使进一步调查.
研究的目的:
- 研究血液中维生素B12度与AN患者的临床,生化和血液学特征之间的关系.
- 为了确定维生素B12缺乏与过量在神经性厌食症患者中的患病率.
主要方法:
- 在营养治疗前对71名日本女性患者的AN数据进行了回顾性分析.
- 使用了斯皮尔曼的等级相关性,费舍尔的精确测试,曼-惠特尼U测试和二进制后勤回归.
- 研究了维生素B12水平与各种生物学,血液学和临床变量之间的关联.
主要成果:
- 22%的AN患者的维生素B12水平升高,而只有2.8%的患者缺乏维生素B12.
- 维生素B12度与年龄,血液尿素和肝酶 (AST,ALT,GT) 有正相关.
- 在维生素B12水平和体重指数 (BMI) 之间观察到负相关性;高的B12与更高的ALT,总蛋白质,肌素和年龄有关.
结论:
- 过度的维生素B12在AN患者中比缺乏更为常见,这表明应该重新评估常规补充剂.
- 维生素B12的升高可能与饥饿引起的肝脏自有关.
- 需要进一步的研究,以了解高维生素B12在AN的物理并发症中的作用.
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