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在HBeAg阳性分娩后妇女中,核酸相似物再治疗后HBsAg意外下降:试点研究

Qiao Tang¹, Chunrui Wang¹, Hu Li¹

¹Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Virology journal

|February 13, 2025

概括

停止核类比 (NA) 治疗慢性乙型肝炎 (CHB) 产后是安全的. 在停止治疗后重新使用NAs可以导致乙型肝炎表面抗原 (HBsAg) 的显著降低,有助于功能治愈.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

乙型肝炎病毒 (HBV) 的母婴传播 (MTCT) 是一个严重的问题.
关于预防慢性乙型肝炎 (CHB) 中MTCT的核酸相似物 (NA) 的以前的研究是有限的.
在停止NA治疗后产后和再治疗疗效后病毒学变化的数据很少.

研究的目的:

为了调查CHB患者在停止NA治疗后产后的病毒学变化.
评估在CHB患者中NA再治疗的疗效.
评估 HBeAg阳性孕妇中断产后NA治疗的安全性.

主要方法:

进行了一项回顾性-前性现实世界试点队列研究.
包括怀孕前接受NA,产后停止治疗或接受重新治疗的患有CHB的孕妇.
在随访期间收集的生物化学和病毒学数据 (HBsAg,HBeAg,HBV DNA).

主要成果:

在产后停止NA治疗后,HBeAg清除和HBsAg减少的发生率较低.
与怀孕前治疗相比,重新治疗患者的HBsAg,HBeAg和HBV DNA显著减少.
在重新治疗患者中,HBsAg降低的累积发病率更高.
在HBeAg阳性孕妇中,产后停止治疗被认为是安全的.

结论:

停止产后NA治疗的HBeAg阳性患者可以从随后的NA再治疗中受益.
重新治疗可能会导致HBsAg显著下降,可能有助于功能治愈.
产后NA停止是CHB患者的安全策略.

关键词:

在ALT中出现异常.肝脏纤维化肝脏纤维化母婴传播是从母亲传播给孩子的.停止治疗停止治疗病毒学反应反应

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