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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

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在HBeAg阳性分娩后妇女中,核酸相似物再治疗后HBsAg意外下降:试点研究.

Qiao Tang¹, Chunrui Wang¹, Hu Li¹

¹Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Virology journal

|February 13, 2025

概括

此摘要是机器生成的。

停止核类比 (NA) 治疗慢性乙型肝炎 (CHB) 产后是安全的. 在停止治疗后重新使用NAs可以导致乙型肝炎表面抗原 (HBsAg) 的显著降低,有助于功能治愈.

关键词:

在ALT中出现异常.肝脏纤维化肝脏纤维化母婴传播是从母亲传播给孩子的.停止治疗停止治疗病毒学反应反应

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科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

乙型肝炎病毒 (HBV) 的母婴传播 (MTCT) 是一个严重的问题.
关于预防慢性乙型肝炎 (CHB) 中MTCT的核酸相似物 (NA) 的以前的研究是有限的.
在停止NA治疗后产后和再治疗疗效后病毒学变化的数据很少.

研究的目的:

为了调查CHB患者在停止NA治疗后产后的病毒学变化.
评估在CHB患者中NA再治疗的疗效.
评估 HBeAg阳性孕妇中断产后NA治疗的安全性.

主要方法:

进行了一项回顾性-前性现实世界试点队列研究.
包括怀孕前接受NA,产后停止治疗或接受重新治疗的患有CHB的孕妇.
在随访期间收集的生物化学和病毒学数据 (HBsAg,HBeAg,HBV DNA).

主要成果:

在产后停止NA治疗后,HBeAg清除和HBsAg减少的发生率较低.
与怀孕前治疗相比,重新治疗患者的HBsAg,HBeAg和HBV DNA显著减少.
在重新治疗患者中,HBsAg降低的累积发病率更高.
在HBeAg阳性孕妇中,产后停止治疗被认为是安全的.

结论:

停止产后NA治疗的HBeAg阳性患者可以从随后的NA再治疗中受益.
重新治疗可能会导致HBsAg显著下降,可能有助于功能治愈.
产后NA停止是CHB患者的安全策略.