来自Heracleum sphondylium亚种根的抗炎化合物. 循环碳化合物 循环碳化合物 循环碳化合物
Ekin Kurtul1, Özlem Bahadır Acıkara2, Büşra Karpuz Ağören3
1Department of Pharmacognosy, Faculty of Pharmacy, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Chemical biology & drug design
|February 14, 2025
概括
赫拉克勒姆斯芬迪利姆 (Heracleum sphondylium) 亚品种的植物. 环卡根显示出显著的抗炎作用. 赫拉克伦醇-3′′-O-β-葡萄糖酸显示出强大的抑制炎症,表现优于植物提取物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 自然产品化学 自然产品化学
背景情况:
- 赫拉克勒姆L.属,被称为Hogweed,在传统医学中广泛用于各种疾病.
- 这种属中的植物尤其因其在治疗炎症病的有效性而受到认可.
研究的目的:
- 为了研究Heracleum sphondylium亚种的抗炎性质. 循环粉根. 循环粉根.
- 隔离和确定负责观察到的抗炎活性的特定化合物.
主要方法:
- 使用生物活性指导分成法,从根提取物中分离活性化合物.
- 卡拉基南和前列腺素E2诱导的炎症模型被用于评估抗炎活性.
- 半准备性高性能液体染色学 (HPLC) 用于化合物隔离.
主要成果:
- 二甲和甲醇提取物表现出显著的抗炎活性.
- 他们分离了五种库马林衍生物:赫拉克伦醇,比坎吉利,赫拉克伦醇-3′′-O-β-葡萄糖化物,比坎吉利-3′′-O-β-葡萄糖化物和梅兰水合物III.
- 与其他孤立化合物和原始提取物相比,Heraclenol-3′′-O-β-glucoside显示出优越的抗炎活性.
结论:
- 赫拉克勒姆斯芬迪利姆 (Heracleum sphondylium) 亚品种的植物. 赛克洛卡根具有显著的抗炎功能.
- 赫拉克伦-3′′-O-β-葡萄糖酸是一种关键活性化合物,在减少炎症方面具有显著的有效性.
相关概念视频
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
92
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
92
02:28Cycloalkanes
12.0K
Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
12.0K
01:29Drugs for Treatment of Ulcerative Colitis in IBD
118
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
118
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
213
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
213
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
135
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
135
01:28Inflammatory Response
1.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.8K