[通过新辅助化疗保护膀的案例,用于膀侵袭的西格结肠癌]
Shoko Iida1, Yoshitoshi Ichikawa, Masakazu Miyake
1Dept. of Surgery, Rinku General Medical Center.
Gan to kagaku ryoho. Cancer & chemotherapy
|February 14, 2025
概括
一名76岁的女性患有晚期西格状结肠癌,侵袭了膀,接受了新辅助化疗. 治疗导致部分反应,使得成功的手术和14个月没有复发.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 与膀入侵的西格结肠癌是一个复杂的临床挑战.
- 尿路症状和的尿液可以表明有局部侵袭的晚期恶性瘤.
研究的目的:
- 报告一个晚期西格状结肠癌与膀侵袭的病例.
- 为了评估新辅助化疗和随后的辅助治疗在这个患者的疗效.
主要方法:
- 诊断包括成像 (CT) 和结肠镜,分期为cT4bN1bM0 (IIIc阶段).
- 新辅助化疗包括卡佩西塔,氧沙和贝瓦西祖马布.
- 手术治疗包括结肠静脉切除,随后是辅助化疗.
主要成果:
- 新辅助化疗实现了部分反应 (PR).
- 新辅助疗法后的病理阶段是ypT4bN1aM0 (IIIc阶段),组织学效应得分为2.
- 患者在手术后和辅助化疗后的14个月内没有复发.
结论:
- 包括新辅助化疗,手术和辅助化疗在内的多式疗法可以有效治疗膀侵袭的晚期西格结肠癌.
- 早期诊断和及时治疗对于管理局部晚期结肠直肠癌至关重要.
- 这一案例凸显了定制瘤治疗策略带来有利结果的潜力.
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