[一种SP142/22C3双阳性和BRCA突变阳性的晚期乳腺癌病例]
Mariko Nishikawa1, Wataru Goto, Juri Maeda
1Dept. of Breast Surgical Oncology, Osaka Metropolitan University Graduate School of Medicine.
Gan to kagaku ryoho. Cancer & chemotherapy
|February 14, 2025
概括
本案例研究详细介绍了一名患有晚期三阴性乳腺癌 (TNBC) 的患者. 尽管有多种疗法,包括免疫疗法和化疗,癌症仍在进展,这突显了治疗的挑战.
科学领域:
- 在瘤学瘤学.
- 医学瘤学 医学瘤学
- 翻译癌症研究 翻译癌症研究
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有有限向治疗选择的侵袭性亚型.
- 转移性TNBC带来了重大治疗挑战,通常需要多式联络方法.
- 本报告侧重于一个特定的患者与高级TNBC的旅程及其治疗过程.
研究的目的:
- 记录患有第四阶段TNBC的患者的临床过程和治疗反应.
- 为了说明管理耐火转移性TNBC的挑战.
- 为高级TNBC的顺序治疗策略提供见解.
主要方法:
- 通过核心针活检证实了TNBC的诊断.
- 分期包括评估原发性瘤和淋巴结转移 (cT2N3M1).
- 针对PD-L1表达的免疫组织化学分析 (SP142和22C3测定).
- 连续使用各种疗法:阿特佐利祖马布 + 纳布 - 帕克利塔塞尔,潘布罗利祖马布 + 卡博普拉丁 + 格米西塔丁,奥拉巴里布,帕克利塔塞尔 + 贝瓦西祖马布和埃里布林.
主要成果:
- 最初用阿特佐利祖马布+纳布-帕克利塔塞尔治疗导致疾病进展 (PD).
- 第二线治疗实现了部分响应 (PR),但在6个月内随后出现PD.
- 随后使用olaparib和paclitaxel + bevacizumab的治疗也导致了PD.
- 患者目前正在接受埃里布林治疗.
结论:
- 具有广泛的淋巴结转移的高级TNBC构成了重大的治疗挑战.
- 顺序治疗策略可能提供暂时的好处,但往往会遇到阻力.
- 需要进一步的研究来确定耐火转移性TNBC的更有效的治疗方法.
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