[与irAE相关的术后静脉静脉狭窄症在胃癌的胃切除术后]
Ibuki Shibata1, Shuhei Komatsu, Tomoki Konishi
1Dept. of Digestive Surgery, Japanese Red Cross Kyoto Daiichi Hospital.
Gan to kagaku ryoho. Cancer & chemotherapy
|February 14, 2025
概括
与免疫相关的不良事件 (irAE) 可以导致胃癌手术后的静脉狭窄症等并发症,即使是免疫检查点抑制剂 (ICI) 治疗. 这个案例显示,用类固醇改善了狭窄,突出显示了ICI相关并发症的潜在管理策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 手术瘤学手术瘤学
背景情况:
- 免疫检查点抑制剂 (ICI) 治疗在癌症治疗中取得了进展,但可能导致与免疫相关的不良事件 (irAE).
- 接受胃癌手术的患者可能会出现并发症,包括irAE,影响恢复.
- 门狭窄症是一种潜在的手术并发症,它可能会被irAE加剧.
研究的目的:
- 报告一个严重的免疫相关不良事件 (irAE) 的病例,导致胃癌机器人胃切除术后的静脉狭窄.
- 用类固醇治疗来说明与irAE相关的静脉静脉狭窄症的成功管理.
- 为了解ICI治疗患者手术并发症的管理做出贡献.
主要方法:
- 一名61岁的男性患者患有双重癌症 (晚期肺癌和胃癌),接受了基于ICI的化疗 (碳白,佩米特雷克塞德,布罗利祖马布).
- 患者在治疗后出现了药物诱导的肺炎和皮肤肌炎,以及严重的irAE.
- 进行了机器人胃切除术,随后观察并治疗了静脉静脉狭窄症.
主要成果:
- 该患者在ICI化疗期间经历了严重的irAE,包括药物诱导的肺炎和皮肤肌炎.
- 机器人胃切除术后出现的解剖狭窄症.
- 狭窄症成功地用类固醇治疗治疗,在2年内没有复发或症状.
结论:
- 与免疫相关的不良事件 (irAE) 可以表现为手术并发症,如在接受免疫检查点抑制剂 (ICI) 治疗的患者的静脉狭窄症.
- 类固醇治疗可以有效治疗与irAE相关的静脉静脉狭窄症.
- 这一案例凸显了在瘤外科手术的背景下识别和管理irAE的重要性.
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