更多的习惯性体力活动改变了热和亚临床心血管疾病风险之间的关系
Sarah Witkowski1, Tint Tha Ra Wun1, JoSophia Brunzelle1
1Department of Exercise & Sport Studies, Smith College, Northampton, Massachusetts, USA.
适度至剧烈的体力活动 (MVPA) 可能会保护绝经前妇女免受热对心血管健康的负面影响. 较高的MVPA可能会否定热和内皮功能下降之间的联系.
科学领域:
- 心血管健康 心血管健康
- 绝经研究 绝经研究
- 内皮细胞功能 内皮细胞功能
背景情况:
- 更年期过渡增加了心血管疾病 (CVD) 的风险.
- 热 (HF) 是一种常见的绝经症状,与较高的心血管疾病风险有关.
- 内皮功能障碍,通过流媒扩张 (FMD) 表示,是与HF相关的早期心血管疾病标志物.
研究的目的:
- 调查是否适度至剧烈的体力活动 (MVPA) 影响了绝经前妇女中HF和口炎之间的关系.
- 为了确定MVPA对客观HF和内皮功能之间的关联的缓和作用.
主要方法:
- 在24小时内使用胸部皮肤导电率进行客观HF测量.
- 通过7天的动画绘制进行MVPA评估.
- 支臂动脉口炎测量以评估内皮功能.
- 统计分析包括相关性,多重回归和简单斜率分析.
主要成果:
- 较低的口病往往与更高的客观高频率相关,特别是在清醒时间.
- 在对年龄和BMI进行控制后,HF和HF-MVPA相互作用显著预测了口病.
- 只有在较低的MVPA水平下才观察到HF和口病之间的显著负面关系;这种关系在较高的MVPA中是缺席的.
结论:
- 在绝经前妇女中,MVPA似乎可以缓解客观热和内皮功能之间的关联.
- 在更年期过渡期间,更高水平的体力活动可能会减轻热对血管健康的有害影响.
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