介素-38作为潜在的心力衰竭诊断生物标志物
Hongman Liu1, Mingliang Zhang1, Wen Gong1
1Department of Cardiology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
Biomarkers in medicine
|February 14, 2025
概括
在心力衰竭 (HF) 患者中,介素-38 (IL-38) 水平较高. 将IL-38与年龄和性别相结合,可以改善HF诊断,为心血管疾病提供新的潜在生物标志物.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 众所周知,互乐金-38 (IL-38) 可以减轻炎症和心肌损伤.
- IL-38在降低心力衰竭 (HF) 发病率的潜在作用需要进行心肌梗塞后的研究.
研究的目的:
- 评估血清IL-38水平对心力衰竭 (HF) 的诊断价值.
- 评估IL-38与HF风险的关联,考虑人口因素.
主要方法:
- 酶相关免疫吸收试验 (ELISA) 用于测量238名高血压患者和30名健康对照者的血清IL-38.
- 采用接收器操作特征 (ROC) 分析和多变量回归来确定诊断和预测值.
主要成果:
- 与对照组相比,HF患者的血清IL-38水平显著升高 (p=0.002).
- 对于HF预测,IL-38表现出0.676的曲线下的区域 (AUC) 是中等的.
- IL-38独立地与更高的HF风险相关 (OR=1.493-1.500,p<0.01).
- 将IL-38与年龄和性别相结合,显著改善了HF预测 (AUC=0.796).
结论:
- 血清IL-38在心力衰竭患者中增加.
- 特别是当与年龄和性别相结合时,IL-38显示出作为HF诊断生物标志物的希望.
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