婴儿需要用nirsevimab免疫,以防止一个RSV住院,西班牙,2023/24赛季
Roberto Pastor-Barriuso1,2, Olivier Núñez1,2, Susana Monge1,3
1National Centre of Epidemiology, Institute of Health Carlos III, Madrid, Spain.
概括
尼尔塞维玛可显著减少呼吸道同胞病毒 (RSV) 的住院治疗. 产时免疫比追赶更具成本效益,最佳时间是RSV季节的高峰期.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 卫生经济学 卫生经济学
背景情况:
- 呼吸道共囊病毒 (RSV) 是导致婴儿住院的首要原因.
- 有效的预防措施对于减少RSV疾病的负担至关重要.
- 尼尔塞维玛提供了对RSV的被动免疫.
研究的目的:
- 为了估计用nirsevimab免疫接种所需的数量 (NNI).
- 计算nirsevimab用于预防RSV住院治疗的成本效益.
- 分析婴儿出生时间相对于RSV季节的影响.
主要方法:
- 分析来自西班牙的现实世界数据 (2023年10月 - 2024年3月).
- 估计NNI和每次预防住院治疗的成本.
- 分析的分层是按免疫策略 (出生时与追赶) 和出生月份进行的.
主要成果:
- NNI是90名婴儿 (费用:19700欧元) 的补充免疫接种.
- NNI是41名婴儿 (费用:9000欧元) 在出生时进行免疫接种.
- 在RSV流行病峰值之前出生的婴儿中观察到较低的NNI和成本.
结论:
- 使用nirsevimab的出生免疫比追赶免疫更具成本效益.
- 与RSV季节相比,优化免疫时间提高了成本效益.
- 尼尔塞维玛是预防婴儿RSV住院治疗的宝贵工具.
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