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在低温的幼儿中严重细菌感染的患病率,呼吸道病原体检测呈阳性
Madhuri Prasad1, John M Morrison1,2, Sumeet L Banker3,4
1Division of Pediatric Hospital Medicine, Johns Hopkins All Children's Hospital, St Petersburg, FL.
在患有低温的婴儿中,呼吸道病原体检测没有预测严重或侵入性的细菌感染. 需要进一步的研究来确定这种测试对风险分层的有用性.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 新生儿科学 新生儿科学
背景情况:
- 婴儿的低温可能是严重细菌感染 (SBI) 的迹象.
- 呼吸道病原体检测有时用于评估发烧的婴儿.
- 在患有低温的婴儿中进行呼吸道病原体检测的实用性尚未得到充分证实.
研究的目的:
- 根据呼吸道病原体测试结果,比较婴儿低温严重细菌感染 (SBI) 和侵入性细菌感染 (IBI) 的患病率.
- 评估呼吸道病原体检测和SBI/IBI在患有低温的婴儿之间的关联.
主要方法:
- 婴儿≤90天低温 (≤36°C) 的多中心回顾性队列研究.
- 婴儿中SBI和IBI患病率的比较,呼吸道病原体检测呈阳性和阴性.
- SBI被定义为阳性血液,尿液或脑脊液培养和抗生素治疗;IBI被定义为细菌病和/或脑膜炎.
主要成果:
- 在40.6%的婴儿中进行了呼吸道病原体检测;24.9%的受试者呈阳性.
- 在该队列中,SBI的患病率为7.4%,IBI为4.5%.
- 在阳性呼吸道病原体测试结果和SBI或IBI的流行率之间没有发现显著的关联.
结论:
- 大多数患有低温的婴儿没有接受呼吸道病原体检测.
- 阳性呼吸道病原体测试结果与SBI或IBI的风险增加无关.
- 需要进一步的研究来澄清呼吸道病原体检测在低温婴儿风险分层中的作用.
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