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二氧化碳微分激光诱导皮肤微道热损伤模式:一个模拟研究

Ali Shorakaie¹, Elaheh Nahvifard¹, Afshan Shirkavand²

¹Physics Department, Science Faculty, Imam Khomeini International University, Qazvin, Iran.

Journal of lasers in medical sciences

|February 14, 2025

概括

优化二氧化碳微分激光设置,特别是10W功率和更长的脉冲持续时间,可以创建有效的微道用于药物输送,同时最大限度地减少皮肤组织的热损伤.

科学领域:

生物医学工程生物医学工程
皮肤病学皮肤病学
激光物理激光物理

背景情况:

分数CO2激光器创建微道,用于复苏和药物输送.
了解热分布和热损伤对于优化激光治疗至关重要.
尽量减少附带热损伤对于安全有效的激光程序至关重要.

研究的目的:

模拟二氧化碳微分激光器的热分布和热损伤模型.
优化激光参数 (大小,脉冲持续时间,功率) 以改善药物输送应用.
评估不同激光设置对组织保存的影响.

主要方法:

使用了COMSOL多物理软件进行热建模.
模拟皮肤为三个同质的层:表皮,皮肤和皮下皮肤.
定义的参数包括0.07毫米的点尺寸,10-15瓦的功率和0.5-15毫秒的脉冲持续时间.

主要成果:

具有不同脉冲持续时间的10W功率产生了最佳的微道,损伤最小.
高功率 (>15W) 和短脉冲 (例如5脉冲) 导致显著的组织损伤.
在10W功率下增加脉冲持续时间减少了周围组织损伤.

结论:

二氧化碳分数激光器通过吸收光和热量产生诱导微道.
微道之间的更大的间距与更好的组织保存有关.
对于临床前激光治疗优化,COMSOL软件显示出有前途的潜力.

关键词:

科姆索尔 (COMMSOL) 是一个国家.分数激光激光器的使用.模拟模拟是为了模拟.热损伤热损伤热损伤热分布热分布热分布热分布

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