多发性硬化症中的疲劳:对药物和非药物干预措施的范围审查
Mateo Diaz-Quiroz1, Paula Catalina Chicue-Cuervo2, Luna Garcia-Moreno2
1Neuroscience Research Group (NeURos), Centro de Neurociencia NeURovitae, Cra 24#63C-69, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Multiple sclerosis journal - experimental, translational and clinical
|February 14, 2025
概括
多发性硬化症 (MS) 疲劳的药理疗法显示效果有限. 非药物干预措施,如认知行为疗法和运动,显著减少MS疲劳,表明需要多学科管理.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 疲劳是多发性硬化症 (MS) 中的主要致残症状.
- 有效管理MS相关的疲劳对于患者的生活质量和疾病负担至关重要.
- 对于MS疲劳的干预措施的现有证据需要全面的综合和更新.
研究的目的:
- 进行范围审查,综合有关MS相关疲劳的药理和非药理干预措施的证据.
- 更新对多发性硬化症患者疲劳的有效治疗方法的理解.
主要方法:
- 在2016年至2023年期间发表的随机对照试验 (RCT) 的系统文献搜索.
- 遵守系统性审查和元分析协议的优先报告项目,扩展范围审查 (PRISMA-ScR) 准则.
- 对28个选定的RCT进行分析.
主要成果:
- 很少有药理干预措施 (阿曼塔丁,奥丹塞,甲基酸盐,莫达菲尼尔) 对MS疲劳的影响很小.
- 不同的非药物干预措施,包括认知行为疗法,指导图像,光疗,运动,大脑刺激和衣草管理,显示了统计学上显著的疲劳减轻.
- 对药理干预的证据仍然有限.
结论:
- 目前关于MS疲劳的药理干预措施的证据是不确定的.
- 非药理学方法在缓解多发性硬化症疲劳方面显示出有希望的结果.
- 一个全面的,跨学科的方法对于管理MS相关的疲劳是必不可少的,因为不完全理解其病理生理学.
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