儿科亚急性/慢性焦点骨淋巴腺症中恶性瘤的危险因素
Yishai Haimi-Cohen1,2,3, Eyal Elron3,4, Lital Oz-Alcalay5
1Department for Day Hospitalization, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Frontiers in pediatrics
|February 14, 2025
概括
在患有持续部淋巴腺病的儿童中,年龄较大和淋巴结较大是潜在恶性瘤的关键指标. 这些因素有助于指导在儿科病例中进行手术干预的决定.
科学领域:
- 儿科瘤学 儿科瘤学
- 头部和部手术 头部和部手术
- 诊断成像 诊断成像 诊断成像
背景情况:
- 焦点持久隔离的椎骨淋巴腺病在儿童中很常见.
- 恶性瘤的风险通常很低,但识别高风险病例对于及时干预至关重要.
- 关于手术切除的决定需要准确的风险分层.
研究的目的:
- 为了确定与患有焦点持久隔离的骨淋巴腺症的儿童恶性瘤相关的因素.
- 协助临床决策有关小儿病人的节点外科切除.
- 为了提高儿科部质量恶性瘤的诊断准确度.
主要方法:
- 从2008年1月至2020年12月期间接受治疗的儿童的人口和临床数据的回顾性分析.
- 包括来自三级儿科门诊的患有亚急性和慢性骨淋巴腺病的儿童.
- 进行了单变量和多变量分析,以评估恶性瘤的风险因素.
主要成果:
- 在450名儿童中,5.6%被诊断患有恶性瘤.
- 与恶性瘤相关的因素包括年龄较大,结节尺寸较大,特定的淋巴结位置 (关节骨上,侧) 和全身症状.
- 多变量分析证实年龄较大 (OR 1.649每3年) 和淋巴结较大 (OR 2.080每厘米) 是恶性瘤的显著预测因素.
结论:
- 高龄和淋巴结尺寸增加是儿童骨淋巴腺病的恶性瘤风险的重要指标.
- 这些发现支持考虑对患有这些危险因素的儿童进行手术.
- 更好地识别高风险儿科患者可以导致更早的诊断和治疗.
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