儿科移植接受者患有失生症的风险增加
Gizem Yılmaz1, Seha Saygılı2, Ayşe Ağbaş2
1Department of Pediatrics, Cerrahpasa Faculty of Medicine, Istanbul University - Cerrahpasa, Istanbul, Türkiye.
Frontiers in microbiology
|February 14, 2025
概括
儿童移植接受者表现出改变的肠道细菌,其中Verrucomicrobiota增加,Firmicutes减少. 这些变化表明肠道失调,可能会影响移植结果.
科学领域:
- 微生物学 微生物学
- 儿科脏病学 儿科脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在宿主健康和免疫功能中起着至关重要的作用.
- 肠道微生物群的不平衡,即失生症,与各种疾病有关.
研究的目的:
- 为了比较儿科移植 (KTx) 接受者和健康儿童之间的肠道微生物组合.
- 为了确定儿科KTx接受者的特定微生物变化.
主要方法:
- 对30名儿科KTx接受者和25名健康儿童进行的横截面观察研究.
- 16S rRNA基因测序用于肠道微生物群的评估.
- 使用Phyloseq,QIIME2和LEfSe的统计分析.
主要成果:
- 两组之间的α和β多样性没有显著差异.
- 接受KTx的患者表现出Verrucomicrobiota,Akkermansia和Neisseria (p <0.05) 的较高丰度.
- 减少Firmicutes的丰度和增加的细菌丰度在KTx接受者与尿路感染,腹,或减少GFR (p <0.05).
结论:
- 儿科KTx接受者表现出显著的肠道微生物群变化,暗示了dysbiosis.
- 需要进一步的研究来了解这些微生物变化的临床影响和长期后果.
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