相关实验视频

Updated: May 6, 2026

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

杂交的外围神经膜瘤 - 一篇评论

Himani T Chaturvedi¹, Chandrashekher Chaturvedi²

¹Department of Oral Pathology, Faculty of Dental Sciences, Dharmsinh Desai University, Nadiad, Gujarat, India.

Journal of oral and maxillofacial pathology : JOMFP

|February 14, 2025

概括

杂交的外周神经膜瘤 (PNSTs) 是一种罕见的瘤,结合了神经纤维瘤,神经瘤和神经瘤. 这篇评论更新了关于它们的诊断,分子发现和临床行为的知识.

科学领域:

在瘤学瘤学.
病理学病理学病理学
遗传学是一个遗传学.

背景情况:

杂交的外围神经膜瘤 (PNSTs) 是复杂的瘤,包括神经纤维瘤,神经瘤和神经瘤的组合.
这些瘤在2013年世界卫生组织软组织和骨瘤分类中首次被描述,由于其多样化的组织学,这些瘤存在诊断挑战.
常见的变体包括神经瘤-施瓦诺瘤,而神经纤维瘤/施瓦诺瘤组合通常与神经纤维瘤类型1或2有关.

研究的目的:

为提供关于混合外围神经瘤的简短更新.
突出诊断挑战和最近的分子发现.
强调需要对其病原和临床过程保持警.

主要方法:

对诊断的组织病理学和免疫组织化学的审查.
分子数据的分析,包括基因融合和突变.
综合有关混合PNST的当前文献.

主要成果:

混合PNST通常是良性,皮肤或皮下病变.
新发现包括神经纤维瘤/神经瘤中的CHD7-VGLL3融合基因,以及一些神经纤维瘤/神经瘤中的ERBB2突变.
分子病变发生,复发和恶性转变的风险在很大程度上仍未被描述.

结论:

混合PNST需要仔细的病理评估和临床监测.
新兴的分子洞察力为了解病变产生提供了潜在的途径.
进一步的研究对于阐明混合PNST行为的全谱至关重要.

关键词:

良性良性的斯万诺玛是一个人.混合神经膜瘤混合神经瘤神经纤维细胞瘤是什么周围神经瘤 (perineurioma) 是一个

更多相关视频

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

相关概念视频

Peripheral Nervous System: Ganglia and Nerves

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...