基于经过修订的世卫组织标准,使用库尔库明片剂评估白血病变化的临床和组织病理变化 - - 一项试点研究
Parul Khare1, Anshu Gupta Devra2, Madhvika Patidar3
1Department of Oral and Maxillofacial Pathology and Oral Microbiology, In Charge, Unit Forensic Odontology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.
Journal of oral and maxillofacial pathology : JOMFP
|February 14, 2025
概括
黄片可能有助于口腔白血病患者通过减少病变大小和改善他的病理特征. 由于试点研究,需要进行进一步的研究.
科学领域:
- 口腔病理学 口腔病理学
- 自然产品化学 自然产品化学
- 在瘤学瘤学.
背景情况:
- 口腔上皮质发育不良,包括白血病发育不良,携带恶性转变的风险.
- 库尔库是一种具有抗癌性能的天然多,正在作为治疗白血病的潜在治疗剂进行研究.
研究的目的:
- 评估黄素片对口腔白血病的临床和病理学影响.
- 使用世卫组织2022年标准,通过国际专家的独立评估,比较治疗前后的变化.
主要方法:
- 一项试点研究涉及10名口腔白血病患者.
- 三个阶段的方法:初始活检,3个月的黄剂 (2片每天三次) 和每月一次的临床评估.
- 治疗后进行的第二次活检用于组织病理学分析.
主要成果:
- 临床观察:一些患者的病变大小减少和颜色变化 (白色到灰色斑块).
- 组织病理学分析:专家病理学家报告的建筑和细胞学特征的主观改善.
- 表明黄素在治疗轻度口腔发育不良时具有潜在的有用性.
结论:
- 黄片对于口腔白血病患者,特别是轻度发育不良病例的患者来说,表现有前途.
- 样本规模小,需要进行更大规模的研究来证实疗效和长期结果.
- 世卫组织2022年标准表明主观性,但对于跟踪重复活检中的特定变化很有价值.
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