相关实验视频
Updated: May 28, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.5K
用活性维生素D3补充剂通过调节甲状腺内T细胞子集的分化和功能来改善小鼠的实验性自身免疫甲状腺炎
Chun-Mei Wang1, Ying-Jie Chen1, Bo-Cheng Yang1
1Department of General Surgery (Thyroid Surgery), Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Frontiers in immunology
|February 14, 2025
概括
维生素D3补充剂有效治疗小鼠自身免疫性甲状腺炎. 它通过调节免疫细胞功能来减少甲状腺损伤和抗体水平.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 这是一种自身免疫力.
背景情况:
- 哈西莫托甲状腺炎 (HT) 与维生素D3水平较低有关.
- 维生素D3补充剂在减少HT的甲状腺炎症中的作用受到争议.
研究的目的:
- 在小鼠模型中研究维生素D3对自身免疫性甲状腺炎 (AIT) 的治疗作用.
- 在AIT中阐明维生素D3的免疫调节机制.
主要方法:
- 在小鼠中使用化诱导了自身免疫性甲状腺炎.
- 小鼠接受了维生素D3 (1α,25-(OH) 2D3) 的治疗.
- 分析了甲状腺组织学,自身抗体,激素水平和免疫细胞群 (B和T淋巴细胞).
主要成果:
- 诱导性甲状腺炎导致毛囊破坏,淋巴细胞透,甲状腺自身抗体 (TG-Ab,TPO-Ab) 升高和激素水平异常.
- 促炎性T细胞 (Tfh,Th17,Th1,Th2) 增加,而调节性T细胞 (Treg) 和B10细胞减少.
- 维生素D3治疗逆转了这些病理和免疫变化.
结论:
- 维生素D3是对小鼠自身免疫性甲状腺炎的潜在有效治疗方法.
- 维生素D3通过抑制促炎性T细胞和促进抗炎性免疫细胞来改善AIT.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Role of Skin in Vitamin D Synthesis
5.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.0K

