TPMGD:巴基斯坦传统药物的基因组数据库
Rushuang Xiang1,2,3, Huihua Wan1,2, Wei Sun1,2
1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Chinese herbal medicines
|February 14, 2025
概括
一个新的基因组数据库 - - 传统巴基斯坦医学基因组数据库 (TPMGD) - - 已经开发出来,以对抗伪造. 该资源有助于识别和安全的传统巴基斯坦药物,确保质量和保护资源.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 巴基斯坦传统医药 (TPM) 是必不可少的,但由于资源分散和缺乏系统管理,遭受了普遍的改.
- 伪造危害药品使用安全,影响国际贸易,需要标准化识别方法.
研究的目的:
- 为巴基斯坦传统医药 (TPM) 开发一个全面的基因组数据库.
- 建立一个标准化的系统来识别和管理TPM.
- 确保TPM的安全性,有效性和资源保护.
主要方法:
- 汇编了128个TPM的数据,包括药用部件,疗效,使用和来自巴基斯坦哈姆达德药典的遗传材料.
- 利用了NCBI和GPGD的生物信息学和数据,并补充了叶绿体基因组数据.
- 使用LAMP系统和PHP MVC框架为数据库构建了一个Web服务器.
主要成果:
- 开发了传统巴基斯坦医学基因组数据库 (TPMGD),有五个条目:首页,药用物种,物种识别,BLAST和下载.
- TPMGD包含128个TPM的基本配置文件和102个TPM的遗传信息,包括各种DNA序列 (COI,线粒体,ITS2,psbA-trnH,cp-基因组).
- 该数据库整合了物种描述,功能信息,遗传数据和分子识别工具.
结论:
- TPMGD是一个多功能资源,用于TPM信息和分子识别.
- 该数据库为确保药物安全,准确的物种识别和保护TPM资源提供了科学基础.
- 该倡议解决了对巴基斯坦传统药物的管理有系统组织和标准化的迫切需要.
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