通过自然化合物/提取物的慢性消费来改善认知障碍:随机对照试验的系统审查和元分析
Long Ngo Hoang1, Haesung Lee1, Sook Jeong Lee1
1Department of Bioactive Material Sciences and Research Centre of Bioactive Materials, Jeonbuk National University, Jeonju, Jeonbuk-do, Republic of Korea.
Frontiers in aging neuroscience
|February 14, 2025
概括
长期补充天然化合物改善了轻度认知障碍和阿尔茨海默病患者的认知功能. 这篇评论强调了促进认知健康的自然疗法.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的特点是认知能力下降.
- 自然化合物和提取物被探讨了它们对认知功能的潜在治疗作用.
研究的目的:
- 系统地审查和元分析自然化合物或提取物延长补充剂 (≥6周) 在改善MCI或AD患者的认知功能方面的疗效.
主要方法:
- 在主要数据库 (Cochrane,PubMed,PsycARTICLES,Scopus,Web of Science) 进行了全面的文献搜索,截至2024年4月10日.
- 包括随机对照试验,使用迷你精神状态检查 (MMSE) 和阿尔茨海默氏病评估尺度-认知子尺度 (ADAS-Cog) 评估认知结果.
- 分析包括35项研究,共有4974名参与者.
主要成果:
- 在45项相关研究中,有37项显示自然化合物补充后认知结果有所改善或呈现积极趋势.
- 分析显示,ADAS-Cog得分有显著改善 (SMD = -2.88,p < 0.01).
- 在小组分析中观察到MMSE得分改善的趋势 (SMD = 0.76,p = 0.04).
结论:
- 用天然化合物或提取物长时间补充 (≥6周) 对MCI或AD患者显示潜在的认知益处.
- 需要进一步的研究来证实这些发现,并了解潜在的作用机制.
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