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甲状腺癌患者癌症相关认知障碍的风险因素和预测模型
1Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Soochow University Suzhou 215031, Jiangsu, China.
American journal of cancer research
|February 14, 2025
概括
甲状腺癌患者的认知障碍与年龄,并发症和炎症有关. 使用这些因素的预测模型可以识别有风险的个体进行早期干预.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 认知障碍是甲状腺癌患者经常出现的并发症.
- 它受到人口,临床,生化和心理因素的影响.
- 这项研究调查了与癌症相关的认知障碍 (CRCI) 在这一群体中的患病率和决定因素.
研究的目的:
- 分析甲状腺癌患者中CRCI的患病率.
- 确定与CRCI相关的人口,临床,生化和心理因素.
- 开发一种用于识别高风险患者的预测模型.
主要方法:
- 一项对246名甲状腺癌患者进行的回顾性病例对照研究.
- 根据认知功能分组患者,使用迷你精神状态检查 (MMSE).
- 数据包括人口统计,并发症 (CCI),疾病特征,炎症标志物 (IL-6,IL-8,TNF-α,CRP),心理状态 (SDS,SAS,SES) 和睡眠质量 (PSQI). 一个预测模型被开发和验证.
主要成果:
- 较低的认知功能与年龄较大,教育程度较低,CCI较高,疾病持续时间较长,临床阶段较晚,IL-6,IL-8,TNF-α,CRP升高,抑郁症 (SDS) 和焦虑症 (SAS) 评分较高,睡眠质量较差 (PSQI) 有关.
- 拉索回归模型显示出强大的预测性能 (在训练中AUC为0.903,在验证中为0.835).
结论:
- 甲状腺癌患者的CRCI是多因素的,受人口,临床,炎症和心理因素的影响.
- 开发的预测模型可以帮助临床医生识别患有认知障碍高风险的患者.
- 早期识别有助于及时进行干预,以管理CRCI.
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