在格鲁吉亚开发了一种多年期的儿科抗生素图谱,识别了过去十年来抗生素耐药性的变化
Matthew Linam1,2, Madeleine Goldstein1,2, Tracy Huang3
1Division of Pediatric Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|February 14, 2025
概括
格鲁吉亚的儿科抗生素图显示,在十年内,甲素耐药黄金葡萄球菌 (MRSA) 发生率下降,肺炎链球菌 (Streptococcus pneumoniae) 敏感性增加. 这些趋势支持当前针对常见的儿童感染的抗生素治疗指南.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗生素图表对于监测抗生素耐药性模式和指导实证抗生素治疗至关重要.
- 全州范围的儿科抗生素图可以显著提高儿童医院的抗菌药物管理工作.
研究的目的:
- 分析十年 (2014-2023) 格鲁吉亚常见儿科病原体中抗生素敏感性和耐药性的趋势.
- 为了比较对MRSA和大肠杆菌等关键病原体的敏感性的医院间变化.
- 评估抗生素敏感性随时间的变化,以告知临床实践.
主要方法:
- 收集了来自格鲁吉亚五家儿童医院 (2014-2023) 的年度儿科抗生素图.
- 使用的临床和实验室标准研究所针对抗生素编程的指导方针.
- 对常见细菌 (例如,S. aureus,S. pneumoniae,E. coli) 的综合数据和2014年至2023年之间的相比敏感性.
主要成果:
- 在2023年,克林达米辛敏感性为MSSA的78%和MRSA的82%;对S. pneumoniae的阿莫西西林/克拉夫兰酸敏感性为96%.
- 格拉姆阴性细菌对第三代化素 (90-92%) 和美罗 (95-99%) 保持了高度敏感性.
- 从2014年到2023年,MRSA的发病率下降 (49%至33.5%),S. pneumoniae的易感性增加,而大肠杆菌的易感性略有下降,对素,素和美罗的易感性有所下降.
结论:
- 乔治亚州2014-2023年的儿科抗生素图谱数据表明MRSA的下降和S. pneumoniae易感性的改善.
- 格拉姆阴性细菌的敏感性在很大程度上保持稳定,但观察到较小的下降.
- 这些发现支持格鲁吉亚儿童感染的当前抗生素治疗建议.
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