对成年手术患者的抗微生物药物管理是握手的
Abby Kosharek1, Elizabeth Neuner1, Emily Welch1
1Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|February 14, 2025
概括
握手的抗菌药物管理环节减少了成人整体外科病房的整体抗菌药物使用. 这种干预措施显著减少了抗生素的使用,但没有对患者死亡率产生不利影响.
科学领域:
- 传染性疾病 传染性疾病
- 手术护理 手术护理
- 抗微生物药物管理委员会
背景情况:
- 抗微生物耐药性是一个日益增长的全球健康威胁.
- 在手术环境中优化抗微生物药物的使用对于患者的治疗结果和抗药性减轻至关重要.
- 握手抗菌药物管理为改善抗菌药物处方实践提供了一种新的方法.
研究的目的:
- 评估握手抗菌药物管理计划对成人整体外科病房抗菌药物使用的影响.
- 评估面对面,多学科的抗菌药物建议的有效性.
- 确定干预对住院死亡率的影响.
主要方法:
- 回顾性准实验性干预前后研究设计.
- 实施每周握手一次的抗菌药物管理轮,涉及传染病医生和药剂师.
- 对接受全身性抗微生物药物而没有正式传染病咨询的患者病历的审查.
主要成果:
- 总抗菌药物使用量显著下降 (608 vs 542 日治疗/1000 日存在,P = 0.004).
- 立即和持续减少抗生素频谱指数 (P < 0.001).
- 在干预前和干预后期间,医院住院死亡率没有显著差异 (1%对1%,P = 0.791).
结论:
- 每周握手一次的抗菌药物管理计划可以在一般外科病房成功实施.
- 该计划导致抗微生物药物使用量大幅减少.
- 该干预措施没有对医院死亡率产生负面影响,这表明了安全有效的策略.
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