与金属加工液体暴露相关的前列腺癌发病率和死亡率:系统性审查和元分析
Zahra Moradpour1, Amin Barik2, Goljamal Jorjani3
1Department of Occupational Health Engineering, Environmental Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Frontiers in oncology
|February 14, 2025
概括
职业接触金属加工液体 (MWF) 与前列腺癌发病率和死亡率的显著增加有关. 实施工作场所安全措施至关重要,以减少暴露工人的风险.
科学领域:
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 前列腺癌是全球男性的主要癌症.
- 职业暴露,例如金属加工流体 (MWF),是潜在的风险因素.
- 关于MWF与前列腺癌的关联存在有限的综合性研究.
研究的目的:
- 系统地审查和对前列腺癌发病率和死亡率的研究进行元分析.
- 检查MWF暴露与前列腺癌结局之间的关联.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在主要数据库 (PubMed,Scopus,Embase,Web of Science) 进行全面的文献搜索.
- 包括报告MWF暴露和前列腺癌发病率或死亡率的研究;数据提取和两名独立审稿人的偏差风险评估.
主要成果:
- 五项涉及美国汽车工人的研究符合纳入标准.
- 分析显示,前列腺癌发病率的风险增加具有统计学意义 (RR 1.06,95% CI: 1.01-1.11).
- 还观察到前列腺癌死亡率显著增加 (SMR 1.20,95% CI:1.09-1.31).
结论:
- 研究结果表明,MWF暴露与前列腺癌风险和死亡率增加之间存在显著的关联.
- 建议包括加强工作场所安全:工程控制,个人防护设备,液体替代,健康监测和教育.
- 监管机构应根据新出现的证据审查和更新MWF的安全指南.
关键词:
RRR RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRR这是一个SMR.进行元分析.金属加工液体的使用方法疾病发病率 疾病发病率 疾病发病率死亡率 死亡率前列腺癌是前列腺癌.更多相关视频
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