在膝关节骨关节炎的老年患者中,吸入氧混合物作为家庭炼的辅助治疗:一个开放标签,盲目的终点,随机对照试验
Chenhui Wang1, Mengwei Yan2, Yuru Li3
1Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Frontiers in pharmacology
|February 14, 2025
概括
在一项为期12周的试验中,氧 (H2-O2) 吸入显示了膝关节骨关节炎 (KOA) 患者的早期症状缓解. 然而,在治疗的最初两周之后,没有观察到持续的益处.
科学领域:
- 老年学是一门学科.
- 生物医学工程 生物医学工程
- 类风湿病学 类风湿病学
背景情况:
- 膝关节骨关节炎 (KOA) 是一种常见的退行性关节疾病,导致严重的残疾和生活质量的降低.
- 分子 (H2) 具有抗氧化和抗炎性质,但其在骨关节炎中的治疗作用仍未得到充分研究.
- 评估KOA的新疗法潜力对于改善患者的治疗结果和管理这种慢性疾病至关重要.
研究的目的:
- 评估氧 (H2O2) 混合物吸入的治疗效果,作为膝关节骨关节炎 (KOA) 的老年患者的辅助疗法.
- 为了确定H2-O2吸入是否可以改善Koa患者的临床症状和功能状态,这些患者接受了家庭运动计划.
- 在KOA管理的背景下,调查H2-O2吸入对炎症标志物和患者报告的结果的影响.
主要方法:
- 一项随机对照试验涉及121名老年KOA患者,进行了12周.
- 参与者参与了家庭炼 (HBE) 计划;一组每天接受H2O吸入两周,而对照组没有.
- 评估结果使用了西安大略省和麦克马斯特大学的骨关节炎指数 (WOMAC),功能测试 (CST,TUG),炎症标志物和健康调查 (SF-36).
主要成果:
- 虽然两组的WOMAC评分都比基线有所改善,但12周后两组之间的差异在统计学上并不显著 (P = 0.140).
- 一个显著的组 × 时间相互作用表明,H2-O2吸入在HBE计划的最初两周内提供了症状缓解.
- 在12周的随访期间,在功能测试,健康调查得分,坚持或不良事件方面没有发现群体之间的显著差异.
结论:
- 吸入氧 (H2-O2) 表明,在家庭炼计划的前两周内,膝关节骨关节炎 (KOA) 症状暂时缓解,功能活动增强.
- 该研究没有在增加H2-O2吸入时持续改善KOA症状方面取得临床意义.
- 进一步的研究可能是有必要的,以探索最佳的剂量或患者选择在KOA中H2-O2治疗.
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