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相关概念视频

Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

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Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
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Introduction to Urinary System01:13

Introduction to Urinary System

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The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
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Updated: May 28, 2025

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
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尿液中的重金属/微量元素度与功能之间的关联:一项前性研究.

Sisi Xie1, Maïwenn Perrais2,3, Déla Golshayan4

  • 1Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Clinical kidney journal
|February 14, 2025
PubMed
概括

尿液中的重金属和微量元素,如,,,铜,,和,与慢性病 (CKD) 和功能障碍 (IKF) 的风险增加有关. 某些元素也与功能下降的速度更快相关.

关键词:
慢性脏疾病 慢性脏疾病流行病学流行病学球膜过率是指球膜的过率重金属重金属的使用.微量元素的微量元素是什么

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科学领域:

  • 环境健康 环境健康
  • 腎臟病學 (nephrology) 是一種醫學.
  • 毒理学 毒理学 毒理学

背景情况:

  • 慢性病 (CKD) 是一个重大的公共卫生挑战.
  • 横截面研究表明重金属/微量元素与功能下降之间的联系.
  • 未来研究对于确定这些元素在CKD发展和进展中的病原作用至关重要.

研究的目的:

  • 调查尿液中基线重金属/微量元素度与长期功能障碍 (IKF) 或CKD之间的关联.
  • 检查这些因素与功能迅速下降的发生率之间的关系.

主要方法:

  • 一项以人口为基础的前性研究,参与者的平均年龄在基线为51.9岁.
  • 尿液中微量元素度使用诱导合血质谱法进行测量.
  • 功能障碍 (IKF) 被定义为估计的膜过率 (eGFR) 为6090毫升/分钟/1.73米2,CKD为eGFR <60毫升/分钟/1.73米2.
  • 快速EGFR下降被定义为≥3mL/min/1.73m2/year的下降.

主要成果:

  • 在平均12.5年的随访期间,1455名参与者 (31.7%) 患有IKF或CKD,123名 (2.6%) 患有功能迅速下降.
  • 尿液中的,,,铜,,,和与新的IKF或CKD病例的风险增加有关.
  • 尿中的铜,银,和与快速EGFR下降的风险增加有关.

结论:

  • 在一般人群中,几个尿路重金属和微量元素与患上功能障碍或CKD的风险增加有关.
  • 这些元素也与随着时间的推移,功能下降的速度更快有关.
  • 这些发现突出了可能导致病进展的环境因素.