尿液中的重金属/微量元素度与功能之间的关联:一项前性研究
Sisi Xie1, Maïwenn Perrais2,3, Déla Golshayan4
1Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Clinical kidney journal
|February 14, 2025
概括
尿液中的重金属和微量元素,如,,,铜,,和,与慢性病 (CKD) 和功能障碍 (IKF) 的风险增加有关. 某些元素也与功能下降的速度更快相关.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
背景情况:
- 慢性病 (CKD) 是一个重大的公共卫生挑战.
- 横截面研究表明重金属/微量元素与功能下降之间的联系.
- 未来研究对于确定这些元素在CKD发展和进展中的病原作用至关重要.
研究的目的:
- 调查尿液中基线重金属/微量元素度与长期功能障碍 (IKF) 或CKD之间的关联.
- 检查这些因素与功能迅速下降的发生率之间的关系.
主要方法:
- 一项以人口为基础的前性研究,参与者的平均年龄在基线为51.9岁.
- 尿液中微量元素度使用诱导合血质谱法进行测量.
- 功能障碍 (IKF) 被定义为估计的膜过率 (eGFR) 为6090毫升/分钟/1.73米2,CKD为eGFR <60毫升/分钟/1.73米2.
- 快速EGFR下降被定义为≥3mL/min/1.73m2/year的下降.
主要成果:
- 在平均12.5年的随访期间,1455名参与者 (31.7%) 患有IKF或CKD,123名 (2.6%) 患有功能迅速下降.
- 尿液中的,,,铜,,,和与新的IKF或CKD病例的风险增加有关.
- 尿中的铜,银,和与快速EGFR下降的风险增加有关.
结论:
- 在一般人群中,几个尿路重金属和微量元素与患上功能障碍或CKD的风险增加有关.
- 这些元素也与随着时间的推移,功能下降的速度更快有关.
- 这些发现突出了可能导致病进展的环境因素.
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