福福克斯疗法诱导严重的低血与低血和低磁血
Manjappa Mahadevappa1, Kiran Pura Krishnamurthy2, Sakeer Hussain3
1Department of Cardiology, JSS Medical college and Hospital, Mysore, Karnataka, India.
BMJ case reports
|February 14, 2025
概括
福福克斯 (FOLFOX) 化疗方案可能会导致严重的低血,即水平的危险下降. 密切监测和补充剂在治疗胃肠道癌症期间至关重要.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 福福克斯疗法 (leucovorin,5-fluorouracil,oxaliplatin) 是用于结直肠和胃肠道癌症的标准化疗法.
- 低血是与FOLFOX相关的潜在不良药物反应,以及其他代谢和血液学影响.
- 化疗引起的副作用,如腹,恶心和吐,以及脏损失,有助于低血.
研究的目的:
- 为了强调在接受FOLFOX化疗的患者中严重低血的风险.
- 讨论FOLFOX治疗期间导致低血的机制,包括氧沙的作用.
- 强调在接受FOLFOX的患者中电解质监测和管理的重要性.
主要方法:
- 病例报告详细介绍了一名患有严重低血清症的患者.
- 在FOLFOX化疗的背景下对低血的潜在原因的审查.
- 讨论化疗期间低血的临床管理策略.
主要成果:
- 一名患者在没有心律失常的情况下在FOLFOX治疗期间经历了严重的低血 (1.4 mmol/L).
- 奥克萨利普拉丁,特别是5%的乳糖输液,可以通过细胞内转移诱导低血清症.
- 有效的管理包括密切监测电解质和及时补充.
结论:
- 严重的低血是与FOLFOX疗法相关的重大风险.
- 积极的电解质监测和管理,包括补充,对于患者的安全至关重要.
- 解决化疗引起的副作用对于尽量减少损失至关重要.
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