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相关概念视频

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Antibody Structure and Classes01:25

Antibody Structure and Classes

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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
737
Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.0K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

490
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
490
Affinity and Avidity01:41

Affinity and Avidity

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Overview
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相关实验视频

Updated: May 28, 2025

Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF
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Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF

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组合Fc修改用于补充抗体功能.

Yannic C Bartsch1,2, Nicholas E Webb1, Eleanor Burgess1

  • 1Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts, USA.

mAbs
|February 14, 2025
PubMed
概括
此摘要是机器生成的。

结合治疗单克隆抗体 (mAbs) 的工程Fc变体,可以增强功能. 补充Fc修饰的战略选择,特别是具有明显的抗体特异性,扩大了功能活动.

关键词:
具有广泛功能性的抗体.在Fc-修改.补充组合的补充组合.

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A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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科学领域:

  • 免疫学和生物技术
  • 蛋白质工程和抗体治疗学

背景情况:

  • 治疗性单克隆抗体 (mAbs) 是重要的生物药物.
  • Fc工程提供了一种提高mAb效应器功能的方法.
  • 结合工程 mAbs 可能会导致协同效应的治疗效益.

研究的目的:

  • 研究配对的mAbs与不同的Fc修饰的功能互补性.
  • 评估Fc工程对HIV-1抗体库中的mAb活性的影响.
  • 确定结合Fc变体是否可以增强功能广度和活动.

主要方法:

  • 使用了两个HIV-1单克隆抗体 (mAb) 库.
  • 每个库包含60个不同的工程 Fc 变体.
  • 评估了各种Fc修饰的mAb对的体外活性.

主要成果:

  • Fc工程的影响取决于特定抗体 (Fab) 克隆.
  • 来自不同Fabs的Fc变体的组合显示出比具有相同Fab特异性的更大的功能增强.
  • 一些Fc变异组合产生了附加效应,而另一些则是有害的,表明不可预测的结果.

结论:

  • 在mAb组合中补充Fc修改显示了增强功能活动和广度的潜力.
  • Fc变种的战略配对,特别是具有不同特异性的,是关键.
  • 需要进一步的研究来优化Fc修改以获得体内疗效.