在约旦的年轻,住院儿童中使用抗生素,2010-2023年
Haya Hayek1, Justin Z Amarin1,2, Olla Hamdan1
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Microbiology spectrum
|February 14, 2025
概括
在约旦,超过90%的住院儿童接受了抗生素治疗,即使病毒感染很常见,细菌感染很少发生. 这凸显了对抗生素管理和诊断在低资源环境中更好地进行抗生素管理和诊断的关键需求,以对抗抗生素耐药性.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 不适当使用抗生素是抗菌素耐药性的主要驱动因素,是全球健康的重大威胁.
- 了解低资源环境中的抗生素处方模式对于开发有针对性的干预措施至关重要.
- 约旦在医疗保健系统内优化抗生素使用方面面临挑战.
研究的目的:
- 为了调查在约旦安曼住院的两岁以下儿童的抗生素处方做法.
- 评估抗生素使用与已诊断的感染,特别是病毒与细菌病因之间的协调性.
- 确定在缺乏资源的医院环境中改善抗生素管理的领域.
主要方法:
- 从2010年至2013年,2020年和2023年进行了前性病毒监测研究.
- 数据包括抗生素使用情况,人口统计信息以及血液,尿液和脑脊液培养结果.
- 使用世界卫生组织的AWaRe系统对抗生素进行分类;通过RT-PCR检测到呼吸道病毒.
主要成果:
- 在4724名儿童中,92.6%的儿童在住院期间接受了抗生素治疗.
- 抗生素,特别是来自世卫组织观察小组 (97.0%) 的抗生素被广泛使用.
- 在82.8%的儿童中检测到呼吸道病毒,而只有13.9%的培养表明了细菌感染.
结论:
- 在患有主要病毒感染的儿童中广泛使用抗生素表明治疗和疾病病因之间存在很大的差距.
- 跨越研究年和诊断的一致的处方实践强调了系统干预的必要性.
- 加强诊断能力和促进合理使用抗生素对于打击约旦的抗菌素耐药性至关重要.
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