评估和输血对患者的呼吸功能的影响 β-thalassemia 大型的患者
Dilek Ece1, Güzin Cinel2, Emine Dibek Mısırlıoğlu3
1Department of Pediatric Hematology and Oncology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
患有thalassemia major (TM) 的患者可能会经历肺损伤. 这项研究在TM患者中发现了阻塞性呼吸道疾病和支气管过敏症,即使无症状,也强调了对肺功能监测的必要性.
科学领域:
- 肺部医学 肺部医学
- 血液学 血液学 血液学
- 儿科 儿科 儿科
背景情况:
- 大型血病 (TM) 可以影响肺功能.
- 在TM患者的肺部并发症需要进一步调查.
- 了解红细胞输血对肺功能的影响至关重要.
研究的目的:
- 用肺部测试来评估TM患者的肺部功能障碍模式.
- 评估红细胞输血对TM肺功能的影响.
- 为了确定在TM患者中支气管过敏反应的患病率.
主要方法:
- 在37名患有TM的患者 (9-21岁) 上进行前性研究.
- 输血前和后进行的肺功能测试,包括螺旋计,囊造影和CO扩散.
- 甲胆挑战测试在输血后进行,以评估支气管过敏反应.
主要成果:
- 输血后的螺旋计没有显著变化.
- 输血后观察到肺总容量和生命能力下降.
- 输血后改善了CO扩散能力 (DLCO),其中44.4%显示出初始损伤.
- 在37%的患者中检测到支气管过敏反应.
- 在54%的患者中发现了阻塞性呼吸道疾病.
结论:
- 肌痛转移患者可能有亚临床呼吸系统异常.
- 阻塞性呼吸道疾病是TM患者常见的发现.
- 这项研究首次报告了TM患者支气管过敏的频率.
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Published on: March 14, 2017
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