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Updated: May 28, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Published on: January 3, 2018

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通过2,4-Diamino-1,6-dihydro-1,3,5-triazines扩大双重作用抗叶酸抗菌剂的风景

John D Georgiades1, Daniel A Berkovich2, Samuel R McKee3

  • 1Department of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, United States.

ACS infectious diseases
|February 14, 2025
PubMed
概括

新的双重作用抗叶剂,或DADHTs,提供了对抗抗生素耐药性的有希望的策略. 这些化合物抑制二叶酸减少酶 (DHFR),破坏细菌膜,对具有挑战性的病原体表现出广泛的活性.

关键词:
抗生素抗生素是一种抗生素.抗叶酸盐是一种抗叶酸.双叶酸减少酶是什么双重机制的机制是双重的膜的破坏破坏.三亚的三亚是一种

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