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在使用PI-RADS版本2的前列腺多参数MRI中,虚假阳性和虚假阴性结果的临床和成像预测器

Bassel Salka¹, Jonathan P Troost², Sonia Gaur³

¹Department of Urology, Henry Ford Health System, Detroit, Mich.

Radiology. Imaging cancer

|February 14, 2025

概括

使用PI-RADS v2进行前列腺多参数MRI (mpMRI) 解释可以通过考虑前列腺特异抗原 (PSA) 密度和患者年龄来改善,以减少前列腺癌检测中的假阳性和假阴性结果.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

前列腺多参数MRI (mpMRI) 对于前列腺癌的检测至关重要.
前列腺成像和报告数据系统版本2 (PI-RADS v2) 被广泛用于标准化解释.
假阳性 (FP) 和假阴性 (FN) 结果可能会影响临床决策.

研究的目的:

为了识别假阳性 (FP) 和假阴性 (FN) 结果的预测因子,使用PI-RADS v2.2.的前列腺mpMRI检测前列腺癌.
评估前列腺特异性抗原 (PSA) 密度和患者年龄的独立预测值.

主要方法:

在2548名接受前列腺mpMRI与PI-RADS v2.2.的患者进行了回顾性队列研究.
对未来PI-RADS v2评分,随后的活检结果,患者年龄,病变特征和PSA密度的分析.
使用后勤回归来评估FP和FN结果的预测因素.

主要成果:

FP结果与年轻的年龄,较小的病变,过渡区位置和低PSA密度有关.
FN结果与年龄较大和高PSA密度有关.
PSA密度和患者年龄独立地预测了FP和FN结果.

结论:

前列腺特异性抗原 (PSA) 密度和患者年龄是使用PI-RADS v2.2.的mpMRI检测前列腺癌虚假阳性和虚假阴性的重要独立预测因素.
将这些因素纳入mpMRI解释可能会提高诊断准确度并改善前列腺癌诊断.
这些预测因素目前不是PI-RADS v2评分系统的一部分.

关键词:

在MR成像中使用MR成像.皮拉德斯 (PI-RADS) 是一个前列腺前列腺前列腺前列腺癌是前列腺癌.前列腺核磁共振成像

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