基于机器学习的存活预测工具用于上腺皮层癌
Emre Sedar Saygili1,2, Yasir S Elhassan2,3, Alessandro Prete2,4,3,5
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale Turkey.
The Journal of clinical endocrinology and metabolism
|February 14, 2025
概括
机器学习模型提高了S-GRAS得分,用于预测上腺皮癌 (ACC) 的结果. 这种方法改善了预后分类,并为个性化患者管理提供了一个可访问的网络工具.
科学领域:
- 在瘤学瘤学.
- 医疗信息学 医疗信息学
- 生物统计学 生物统计学
背景情况:
- 上皮层癌 (ACC) 是一种罕见且具有攻击性的癌症,其结果不可预测.
- 结合临床和组织病理因素的S-GRAS评分为ACC患者提供了良好的预后价值.
研究的目的:
- 通过开发先进的机器学习 (ML) 模型来增强ACC的预后分类.
- 为ACC患者创建个性化的风险预测工具.
主要方法:
- 使用大型培训队列 (n=942) 和独立验证队列 (n=152) 开发并验证了ML模型.
- 根据S-GRAS数据集中的单个临床变量构建了16个ML模型.
- 开发了一个基于网络的工具,用于可访问的,个性化的风险预测.
主要成果:
- 性能最好的ML模型 (二次差异分析,光梯度增强机,AdaBoost分类器) 准确地预测了5年的总死亡率和1年和3年的疾病进展.
- 在关键预后终点的培训和验证队伍中获得高F1分.
- 开发的网络工具提供了对死亡率和疾病进展的即时风险估计.
结论:
- 当与强大的ML模型一起使用时,S-GRAS参数对于预测ACC结果是有效的.
- 可访问的网络应用程序通过提供即时风险评估,为ACC患者提供个性化管理决策.
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