在临床试验中扩大三糖类范围:治疗机会
Ask T Nordestgaard1,2, Aruna D Pradhan1, Brendan M Everett1,3
1Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
European heart journal
|February 14, 2025
概括
高水平的甘油三会增加整个生物范围内的心血管风险. 然而,轻度至中度的高甘油三血症可能不会表现出相同的风险增加. 未来的试验应该考虑更广泛的甘油三水平入学.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 目前管理高甘油三的指导方针侧重于2.3至5.6mmol/L之间的水平.
- 这项研究重新评估了整个生物范围的甘油三和心血管风险之间的关联.
研究的目的:
- 评估整个生物范围内的甘油三和心血管风险之间的关联.
- 为了比较轻度至中度高甘油三血症患者与普通人群的心血管风险.
主要方法:
- 使用哥本哈根一般人口研究,妇女健康研究以及PROMINENT,REDUCE-IT和STRENGTH试验的数据计算了主要心血管事件和死亡的危险比率.
- 分析了119,573名全甘油三范围患者和27,757名轻度至中度高甘油三血症患者的数据.
主要成果:
- 在整个范围 (0.3至11.2毫摩尔/升) 中增加的甘油三与更高的心血管事件风险相关.
- 在队列和试验中,较高的甘油三四分位数显示了心血管事件风险的适度增加,但与死亡没有强烈关联.
- 患有轻度至中度高甘油三血症的人没有表现出相同程度的心血管风险.
结论:
- 轻度至中度的高甘油三血症可能不会带来与整个甘油三水平范围内的心血管风险相同的风险.
- 未来的降甘油三治疗试验可以从包括具有更广泛甘油三水平的参与者中获益,不包括患有胰腺炎或过度饮酒的人.
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