IL-34在瘤中的作用及其用于调节炎症的应用
Yuichi Igarashi1, Ken-Ichiro Seino1
1Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Cancer science
|February 14, 2025
概括
介乐-34 (IL-34) 通过促进特定的巨细胞分化,驱动疾病进展和治疗耐药性. 阻断IL-34可以改善癌症治疗,突出其在诊断和治疗方面的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 洲际蛋白-34 (IL-34) 是一种细胞因子,它与殖民地刺激因子-1受体 (CSF-1R) 结合,与无处不在的CSF-1相结合.
- 虽然CSF-1的表达很广泛,但IL-34的表达更受限制,但在各种疾病中增加,影响病理学.
- IL-34和CSF-1都刺激CSF-1R,推动单细胞分化成为影响疾病进展的巨细胞.
研究的目的:
- 审查IL-34.4的特性和作用.
- 讨论IL-34在瘤进展和治疗耐药性的参与.
- 探索IL-34在未来诊断和治疗中的潜在应用.
主要方法:
- 关于IL-34功能及其在疾病中的作用研究的文献综述.
- 分析IL-34对巨细胞分化和免疫反应的影响.
- 在临床前癌症模型中检查涉及IL-34阻断的治疗策略.
主要成果:
- IL-34的表达与瘤的进展和对化疗,放射治疗和免疫检查点阻塞等疗法的耐药性有关.
- 阻断IL-34显著提高了IL-34表达癌症的治疗疗效.
- 诱导IL-34的巨细胞表现出免疫抑制性质,但IL-34也可以增强炎症,表明其复杂的作用.
结论:
- IL-34在癌症进展和治疗耐药性方面发挥着至关重要的作用.
- 向IL-34是一个有前途的战略,可以增强现有的癌症治疗方法.
- IL-34在炎症和免疫中的复杂作用表明了新的诊断和治疗应用的潜力.
相关概念视频
Tumor Immunotherapy
463
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
463
The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
T Cell Types and Functions
897
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
897
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
110
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
110
Inflammatory Response
1.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.8K


